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EC number: 679-526-3 | CAS number: 337906-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data are available to specifically evaluate the reprotoxic effect of the target substance or its sulfate form. During the 90 days toxicity study performed on 1,4-diamino-2methoxymethylbenzene sulfate, male and female reproductive organs of rats were observed. No effects were reported, thus no effect on the reproductive performance could be expected.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Additional information
Administration of Methoxymethyl-PPD-Sulfate by the oral route during organogenesis (Day 6 to 19 of gestation) at dose level of 0, 10, 30 and 90 mg/kg bw/day resulted in NOAEL of 30 mg/kg bw/day for maternal toxicity (based on a transient reduction in mean body weight gain and food consumption ). The NOAEL: 30 mg/kg/bw for methoxymethyl-PPD-Sulfate, corresponds to 30 x 0.61 = 18.3 mg/kg bw for methoxymethyl-PPD-base using the conversion factor of 0.61.
The NOAEL for developmental toxicity was 90 mg/kg bw/day. No data are available to specifically evaluate the reprotoxic effect of the target substance or its sulfate form. During the 90 days toxicity study performed on 1,4-diamino-2methoxymethylbenzene sulfate, male and female reproductive organs of rats were observed. No effects were reported, thus no effect on the reproductive performance could be expected.
The NOAEL for developmental toxicity was 90 mg/kg bw/day for sulfate and corresponds to 90 x 0.61 = 55 mg/kg bw for methoxymethyl-PPD-base.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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