Benzylamine

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: case report

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: No OECD guideline or GLP defined. Several substances tested.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1984

Materials and methods

Study type:

other: Patch test

Endpoint addressed:

skin sensitisation

Principles of method if other than guideline:

Method: other: testing in concentrations of 0.1 % and 1.0 % in ethanol (70 %), 10 control persons. During a period of one year, a48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Benzylamine

EC Number:

202-854-1

EC Name:

Benzylamine

Cas Number:

100-46-9

Molecular formula:

C7H9N

IUPAC Name:

1-phenylmethanamine

Details on test material:

- Name of test material: Benzylamine

Results and discussion

Any other information on results incl. tables

Case report: During a period of one year, a 48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.