Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitization:

A test of the registered substance was performed on skin irritation/corrosion in vivo according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) a certified GLP labs. The study can be ranked as klimisch code 1: reliability without restrictions. The results showed that no toxic effect was found, so the sensitization effect of isosorbide can be concluded as not sensitizing.


Migrated from Short description of key information:
Skin sensitisation (OECD 429): not sensitizing

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
Respiratory sensitisation: not tested

Justification for classification or non-classification

Skin sensitization:

According to Official Journal of the European Union 1272/2008 (CLP) dated December 16th 2008, isosorbide is non-classified in this part.