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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

No effects up to the limit of water solubility for Daphnia magna (EU Method C.2)

Key value for chemical safety assessment

Additional information

There are no short-term aquatic invertebrate toxicity studies available for Fatty acids, C16-18, isopropyl esters (CAS No. 91031-58-2). The assessment of short-term toxicity was therefore based on studies conducted with the structurally similar category members Fatty acids, C16-18, Bu esters (CAS No. 85408-76-0) and isopropyl palmitate (CAS No. 142-91-6). This read across approach is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification in Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

The key study with Fatty acids, C16-18, Bu esters (CAS No. 85408-76-0) was performed as a limit test according to EU Method C.2 and GLP (Wierich, 1998). The test organism Daphnia magna was exposed to the test organism in a static system for 48 hours, at the nominal test concentration of 100 mg/L, prepared as water accommodated fractions (WAF). No immobilisation was observed at any treatment, and an EC50 of > 100 mg/L was reported.

The key study with isopropyl palmitate (CAS No. 142-91-6) was performed according to EU Method C.2 and GLP (Kirch, 1998). The test organism Daphnia magna was exposed to the test substance in a static system for 48 hours, at nominal test concentrations of 1000 and 3000 mg/L (measured initial concentrations 0.72 and 1.68 mg/L). No immobility was observed at any of the test concentrations, and the EC50 was reported to be > 3000 mg/L.

Thus, based on theabove mentioned results, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological short-term effects on aquatic invertebrates are expected up tothe limit ofwater solubility for Fatty acids, C16-18, isopropyl esters (CAS No. 91031-58-2).