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EC number: 292-962-5
CAS number: 91031-58-2
No effects up to the limit of water solubility for Daphnia magna (EU Method C.2)
There are no short-term aquatic invertebrate toxicity studies
available for Fatty acids, C16-18, isopropyl esters (CAS No.
91031-58-2). The assessment of short-term toxicity was therefore based
on studies conducted with the structurally similar category members
Fatty acids, C16-18, Bu esters (CAS No. 85408-76-0) and isopropyl
palmitate (CAS No. 142-91-6). This read across approach is in accordance
with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance
and read across approach. Further justification is given within the
endpoint summary 6.1 and within the category justification in Section
13. In this case of read-across, the best suited (highest degree of
structural similarity, nearest physico-chemical properties) read-across
substance was entered into IUCLID. Nevertheless, as can be seen in the
data matrix of the category justification in Section 13, all reliable
data in the category support the hazard assessment for this endpoint, by
showing a consistent pattern of results.
The key study with Fatty acids, C16-18, Bu esters (CAS No.
85408-76-0) was performed as a limit test according to EU Method C.2 and
GLP (Wierich, 1998). The test organism Daphnia magna was exposed to the
test organism in a static system for 48 hours, at the nominal test
concentration of 100 mg/L, prepared as water accommodated fractions
(WAF). No immobilisation was observed at any treatment, and an EC50 of >
100 mg/L was reported.
The key study with isopropyl palmitate (CAS No. 142-91-6) was
performed according to EU Method C.2 and GLP (Kirch, 1998). The test
organism Daphnia magna was exposed to the test substance in a static
system for 48 hours, at nominal test concentrations of 1000 and 3000
mg/L (measured initial concentrations 0.72 and 1.68 mg/L). No immobility
was observed at any of the test concentrations, and the EC50 was
reported to be > 3000 mg/L.
Thus, based on theabove
mentioned results, and due to the structural and profile
similarities of the substances, as are explained with in the overall
endpoint summary 6.1 it can be concluded that no toxicological
short-term effects on aquatic invertebrates are expected up tothe limit
ofwater solubility for Fatty acids, C16-18, isopropyl esters (CAS No.
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