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Short-term toxicity to fish

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Description of key information

No effects up to the limit of water solubility for Danio rerio (OECD 203)

Key value for chemical safety assessment

Additional information

There are no short-term fish toxicity studies available for Fatty acids, C16-18, isopropyl esters (CAS No. 91031-58-2). The assessment of fish toxicity was, therefore, based on studies conducted with the structurally most similar category members, for which data is available, Fatty acids, C16-18, Bu esters (CAS No. 85408-76-0) and isopropyl palmitate (CAS No. 142-91-6), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

The key study with isopropyl palmitate (CAS No. 142-91-6) was performed according to the guideline ISO 7346-1 (similar to OECD 203), in a semi-static system, using Brachydanio rerio as test organism (Richterich, 2001). The fish were exposed to nominal test concentrations of 1000, 3000 and 10000 mg/L during 96 hours. No mortality was observed at any of the test concentrations, and the LC50 was reported to be >10,000 mg/L.

The key study conducted with Fatty acids, C16-18, Bu esters (CAS No. 85408-76-0) performed according to the guideline ISO 7346-1 (Richterich, 2001). The test organism Danio rerio was exposed to the test substance in a semi-static system for 96 hours, at nominal test concentrations of 1000, 3000 and 10,000 mg/L. No mortality was observed at any of the test concentrations, and the LC50 was reported to be >10,000 mg/L.

Thus, based on theabove mentioned results, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up tothe limit ofwater solubility for Fatty acids, C16-18, isopropyl esters (CAS No. 91031-58-2).

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