Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
Bornan-2-one
EC Number:
200-945-0
EC Name:
Bornan-2-one
Cas Number:
76-22-2
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
not specified
Duration of exposure:
ca. 2 h
Concentrations:
1000mg/m3, 2150 mg/m3, 4640mg/m3, 10000mg/m3
No. of animals per sex per dose:
5 females, 5 males

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 10 000 mg/m³ air
Based on:
test mat.
Clinical signs:
other: na
Body weight:
180-220g

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU