Registration Dossier
Registration Dossier
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EC number: 282-486-6 | CAS number: 84238-17-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment), but used in the Cosmetic Ingredient Review (CIR) assessment report.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Dermal irritation was evaluated after application of coconut oil via 24 h single-insult occlusive patch.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- Cas Number:
- 67701-28-4
- IUPAC Name:
- Glycerides, C8-18 and C18-unsatd.
- Details on test material:
- - Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Undiluted
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 9 animals
- Details on study design:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 8
- Irritant / corrosive response data:
- Not irritating
- Other effects:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under test conditions, the test substance was found to be non-irritating to rabbit skin.
- Executive summary:
In a skin irritation study, undiluted ‘glycerides, C8-18 and C18-unsatd.’ (as coconut oil) was applied to the skin of 9 rabbits by means of a 24 h single-insult occlusive patch.
No irritation was observed after 24 h of treatment (PII = 0).
Under test conditions, the test substance was found to be non-irritating to rabbit skin.
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