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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity of test chemical in guinea pig
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-tert-butylhydroquinone
EC Number:
217-752-2
EC Name:
2-tert-butylhydroquinone
Cas Number:
1948-33-0
Molecular formula:
C10-H14-O2
IUPAC Name:
2-tert-butylbenzene-1,4-diol
Details on test material:
- Name of test material: 2-tert-butylhydroquinone
- Molecular formula: C10H14O2
- Molecular weight: 166.22
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
not specified
Duration of exposure:
24 hrs
Doses:
500-1000 mg/kg
No. of animals per sex per dose:
2
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 500 - < 1 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No data available
Mortality:
Mortality observed between 700-1000 mg/kg bw dose level
Clinical signs:
other: Slight edema,staining and blister like spots. Scattered light eschars,sparse hair and some erythema at 1 wk. Light scars at 2 wks.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Conclusions:
The acute dermal median lethal dose (LD50) of test chemical in guinea pig was found to be >1000 mg/kg of body weight. Acute dermal toxicity of test chemical indicates that it is likely to exhibit acute toxicity by the dermal route in the Category 4.
Executive summary:

Acute dermal toxicity study of test chemical was conducted on guinea pigs at the dose concentration of 700 -1000 mg/kg bw. The test chemical was administered via dermal application. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight edema,staining and blister like spots, scattered light eschars,sparse hair, some erythema at 1 wk and Light scars at 2 wks were observed. Therefore, LD50 value was considered to be <1000 mg/kg bw when rats were treated with test chemical via dermal route.