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EC number: 245-629-3 | CAS number: 23386-52-9
Table 1. Concentration of 2-ethylhexanol-forming compounds in the blood of 2 dogs after dosage with 10 mg/kg DSS
Concentrations expressed in µg/mL DSS equivalents
Time after dosage
Dog S14 (I.V.)
Dog R300 (oral)
-: not determined
Table 2. Excretion of radioactivity by 2 dogs which received 4 mg/kg carbon-14 labeled DSS
% of Dose
Hours after dose
Dog R872 (intravenous)
Dog R613 (oral)
Table 3. Concentration of radioactivity in the plasma of 2 dogs which received 4 mg/kg carbon-14 labeled DSS concentrations expressed in µg/mL DSS
Dog 872 (I.V.)
Dog R6113 (oral)
- no sample obtained
The absorption, excretion and metabolism of dioctyl sodium succinate (DSS) have been investigated in dogs by means of unlabeled and radiolabeled (carbon-14) compound. A peak concentration of radioactivity occurred in the orally dosed animal at 1 hour. Analysis of the urine from the dogs produced values equivalent to 4 -7% of the dose in the 0-24 hour samples. A comparison of an oral and intravenous dose of 4 mg/kg carbon-14 DSS in the dog yielded remarkably similar excretion patterns and metabolic profiles. In each case 71% of the administered radioactivity was excreted in the faeces. Countercurrent distribution curves on the urine of these animals were almost identical.
Table 1. Excretion of radioactivity by 2 rabbits which received 4 mg/kg carbon-14 labeld DSS
Rabbit No. 1 (intravenous)
Rabbit No. 2 (oral)
The absorption and excretion of docusate sodium (dioctyl sodium succinate, DSS) have been investigated in rabbits by means of radiolabeled (carbon-14) compound . The results demonstrate good absorption of the radiolabel by the rabbit following oral dosage, over 90% of administered radioactivity being excreted in the urine. It is concluded that DSS is absorbed intact by the rabbit rather than being hydrolysed in the gastrointestinal tract.
Table 1. Concentrations of 2-ethoxylhexanol forming compounds in the serum of 2 subjects after a single 200 mg dose
of DSS (concentrations expressed in µg/mL DSS)
Hours after dosage
Table 2. Concentrations of 2-ethoxylhexanol forming compounds in the urine of 2 subjects after a single 200 mg dose of
DSS (concentrations expressed in percent of dose)
In man, peak concentrations of docusate sodium in serum occurred at 2 hours after dosage with 200 mg. These values, in two men, were 7,9 and 5,5 µg/mL, similar in magnitude to the plasma concentration seen at 1 hour in the orally dosed dog (7,4 µg/mL) which received 4 mg/kg. The analysis of human serum was done by gas chromatography and that of dog plasma by the radiometric method. The excretion of 2-ethylhexanol derivatives in the urine of man accounted for only a very small amount of the administered dose of docusate sodium, a finding similar to that seen in the urine of the dog. An attempt to compare the urine of man and the dog by analysis of 2-ethylhexanol forming compounds in countercurrent distribution fractions did not yield fruitful results.
Table 1. 24 hour excretion of 2-ethylhexanol-forming compounds by the rat after oral dosage with DSS and 2-ethylhexanol
% of dose excreted
-: not determined
The absorption, excretion and metabolism of dioctyl sodium succinate (DSS) have been investigated. Unlabeled DSS and radiolabeled compound (carbon-14) were used. Using a gas chromatographic procedure, a similarity in percent excretion of dose into urine was observed in rats dosed orally and intravenously, indicating a high degree of absorption of the oral dose. Confirmation of extensive absorption of DSS was obtained through oral dosage of 10 mg/kg carbon-14 labeled compound. Two thirds of the administered radioactivity was found in the urine at 24 hours after dosage. All of the activity was in the form of metabolites (2-ethylhexanol forming compounds).
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