Registration Dossier
Registration Dossier
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EC number: 209-520-4 | CAS number: 583-78-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The article contains a summary rather than a full report.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of monochlorophenols, dichlorophenols and pentachlorophenol in the mouse.
- Author:
- Borzelleca JF, Hayes JR, Condie LW, Egle JL Jr.
- Year:
- 1 985
- Bibliographic source:
- Toxicol Lett. 1985 Dec;29(1):39-42
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not available
- GLP compliance:
- not specified
- Test type:
- other: not soecified
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-dichlorophenol
- EC Number:
- 209-520-4
- EC Name:
- 2,5-dichlorophenol
- Cas Number:
- 583-78-8
- Molecular formula:
- C6H4Cl2O
- IUPAC Name:
- 2,5-dichlorophenol
- Reference substance name:
- Phenol, 2,5-dichloro-
- IUPAC Name:
- Phenol, 2,5-dichloro-
- Test material form:
- not specified
- Details on test material:
- purity 98%
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- other: CD-1 ICR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5 levels, levels not indicated
- No. of animals per sex per dose:
- 10 per sex
20 per dose - Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Based on:
- not specified
- 95% CL:
- >= 1 233 - <= 2 075
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 946 mg/kg bw
- Based on:
- not specified
- 95% CL:
- >= 623 - <= 1 438
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- with LD50 male: 1600 mg/kg bw and LD50 female: 946 mg/kg bw 2,5-dichlorophenol is considered harmful acc. to the CLP-Regulation.
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