Registration Dossier
Registration Dossier
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EC number: 244-491-1 | CAS number: 21643-42-5
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
In accordance with column 2 of REACH Regulation (EC) No 1907/2006, section 9.2.2.1, a study on hydrolysis does not need to be conducted as all long-chain alkyl esters (C12 - C14) are readily biodegradable. Further the water solubility of read across substance (mixture of CAS no. 2156-97-0 and 21643-42 -5) is very low (< 0.2 mg/L at 20 °C)
Nevertheless a supporting study of hydrolysis of the test substance was performed through a calculation using HYDROWIN v2.00. The estimated half-life at pH 8 is 2.38 years and the estimated half-life at pH 7 is 23.8 years.
The test compound lacks a functional group that is hydrolytically reactive.This low potential to hydrolyze is supported by the data developed using the HYDROWIN model (see above).Thus, hydrolysis will not significantly contribute to the removal of laurylacrylate from the environment.
Key value for chemical safety assessment
Additional information
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of tetradecyl acrylate (Q)SAR results were used for assessment of hydrolysis.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Further experimental studies are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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