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EC number: 915-316-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- (no data on starting date) 25-NOV 1996 (date of report)
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 1-phenyloctadecane-1,3-dione and phenylicosane-1,3-dione
- EC Number:
- 915-316-2
- Molecular formula:
- C50H80O4
- IUPAC Name:
- Reaction mass of 1-phenyloctadecane-1,3-dione and phenylicosane-1,3-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Iffa Crédo, 69210 L'Arbresle, France
- Age at study initiation: six weeks old
- Weight at study initiation: 188 +- 2 g for males and 150 +- 5 g for females.
- Fasting period before study: overnight period of approximately 18 hours prior to dosing
- Housing: five rats of the same sex were housed in polycarbonate cages
- Food consumption: A04 C pelleted diet (UAR, 91360 Villemoisson-sur-Orge, France) ad libitum.
- Water consumption: filtered water by a Millipore membrane (0.22 µm), ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS:
- Temperature: 21 +- 2°C
- Humidity: 30 to 70 %
- Air changes: 12 cycles/hour of filtered, non recycled air
- Photoperiod: 12-hour light/dark cycle
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Vehicle:
- Concentration in vehicle: no data
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
- Maximum dose volume: 10 mL/kg - Doses:
- 5000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> mortality and clinical signs: observed frequently during the hours after dosing.
Thereafter, observation at least once a day up to the end of the 14-day observation period. (day 15)
> body weights: determined prior to dosing (day 1), on days 8 and 15.
Body weight gain of the treated animals was compared to that of C.I.T. control animals with the same initial body weight.
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred in males and females
- Clinical signs:
- other: The general behaviour of animals was not affected
- Gross pathology:
- Macroscopic examination of the main organs showed no apparent abnormalities
Any other information on results incl. tables
Table 7.2.1/2: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
5000 |
0 |
0 |
- |
- |
0 |
0 |
- |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the current study, the test item showed no signs of toxicity in female and male rats over a period of 14 days when given orally once at 5000 mg/kg bw. The LD50 can therefore be concluded to be greater than 5000 mg/kg bw. The reaction mass of Stearoylbenzoylmethane and Palmitoylbenzoylmethane is not classified for acute oral toxicity according to the criteria of Annex VI of the Directive 67/548/CEE and according to EU Regulation 1272/2008 (CLP).
- Executive summary:
RHODIASTAB X5 was tested for acute oral toxicity in Sprague-Dawley rats in a limit dose assay.
The test substance, a powder, was administered diluted in corn oil. Animals were fastened overnight prior to treatment. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage in a single oral dose (maximum dose volume of 10 mL/kg b.w).
Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period.
No deaths occurred and no clinical signs were observed during the study. Body weight gain was not affected by treatment. At necropsy, macroscopic examination of main organs showed no abnormalities.
As the acute oral LD50 was found to be greater than 5000 mg/kg b.w. under the conditions of the test, the reaction mass of Stearoylbenzoylmethane and Palmitoylbenzoylmethane is not classified according to Annex VI of the Directive 67/548/CEE and according to EU Regulation 1272/2008 (CLP).
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