Valeronitrile

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

1983

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: test was performed as non-GLP screening test following AFNOR-norm T 90301 of April 1974; results were reported in a short letter report only, therefore the study was considered Klimisch code 4.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: AFNOR T 90301

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Valeronitrile

EC Number:

203-781-8

EC Name:

Valeronitrile

Cas Number:

110-59-8

Molecular formula:

C5H9N

IUPAC Name:

pentanenitrile

Details on test material:

no details mentioned in the report

Sampling and analysis

Analytical monitoring:

no

Details on sampling:

No analytical monitoring performed throughout the test. Concentration of test item solution was analyzed by DOC

Test solutions

Vehicle:

no

Details on test solutions:

120 mg test substance were added to 100 ml water and dispersed in an ultrasonic bath for ten minutes at 20°C, followed by centrifugation for twenty minutes at 5000 t/min. The dissolved fraction 1120 mg/l) was analyzed by DOC.

Test organisms

Test organisms (species):

Daphnia magna

Study design

Limit test:

yes

Total exposure duration:

24 h

Test conditions

Hardness:

no data

Test temperature:

20°C

pH:

no data

Salinity:

freshwater used

Nominal and measured concentrations:

A concentration of 1120 mg/l was tested.

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

802 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 95% CL: 754-851 mg/kg

Effect concentrations 2

Duration:

24 h

Dose descriptor:

other: Equitox

Effect conc.:

1.2 other: Equitox/kg

Nominal / measured:

estimated

Conc. based on:

test mat.

Applicant's summary and conclusion

Validity criteria fulfilled:

no

Remarks:

screening test only

Conclusions:

The 24-h EC50 on Daphnia Magna was found to be 802 mg/l.

Executive summary:

The experiment was performed in 1983 as non-GLP screening test following AFNOR Norm T 90301. Test solution was prepared by dispersion of 120 mg test item in 100 ml water, followed by centrifugation, all at room temperature. Results were summarized in a letter report only, therefore no further details available.

The 24-h EC50 on Daphnia Magna was found to be 802 mg/L.