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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1983
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: test was performed as non-GLP screening test following AFNOR-norm T 90301 of April 1974; results were reported in a short letter report only, therefore the study was considered Klimisch code 4.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: AFNOR T 90301
Deviations:
no
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Valeronitrile
EC Number:
203-781-8
EC Name:
Valeronitrile
Cas Number:
110-59-8
Molecular formula:
C5H9N
IUPAC Name:
valeronitrile
Details on test material:
no details mentioned in the report

Sampling and analysis

Analytical monitoring:
no
Details on sampling:
No analytical monitoring performed throughout the test. Concentration of test item solution was analyzed by DOC

Test solutions

Vehicle:
no
Details on test solutions:
120 mg test substance were added to 100 ml water and dispersed in an ultrasonic bath for ten minutes at 20°C, followed by centrifugation for twenty minutes at 5000 t/min. The dissolved fraction 1120 mg/l) was analyzed by DOC.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Limit test:
yes
Total exposure duration:
24 h

Test conditions

Hardness:
no data
Test temperature:
20°C
pH:
no data
Salinity:
freshwater used
Nominal and measured concentrations:
A concentration of 1120 mg/l was tested.
Reference substance (positive control):
not specified

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
802 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: 95% CL: 754-851 mg/kg
Duration:
24 h
Dose descriptor:
other: Equitox
Effect conc.:
1.2 other: Equitox/kg
Nominal / measured:
estimated
Conc. based on:
test mat.

Applicant's summary and conclusion

Validity criteria fulfilled:
no
Remarks:
screening test only
Conclusions:
The 24-h EC50 on Daphnia Magna was found to be 802 mg/l.
Executive summary:

The experiment was performed in 1983 as non-GLP screening test following AFNOR Norm T 90301. Test solution was prepared by dispersion of 120 mg test item in 100 ml water, followed by centrifugation, all at room temperature. Results were summarized in a letter report only, therefore no further details available.

The 24-h EC50 on Daphnia Magna was found to be 802 mg/L.