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EC number: 939-597-6 | CAS number: 68610-66-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Justification for type of information:
- Please refer to the Category Approach Justification provided in Section 13
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412, part II
- GLP compliance:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: LVA, Düsseldorf, Germany
- Age at study initiation (mean and range, SD): <= 24 h
- Feeding during test: none
Culture conditions
- Culture temperature: 20 ± 1 °C
- Photoperiod: 16 h diffuse light daily
- Type and amount of food: cells of the green algae Scenedesmus spec.
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- pH:
- 7.5-7.9
- Nominal and measured concentrations:
- Nominal test concentrations: control, 8, 16, 32, 64, 128, 256, 512, 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
EFFECT PARAMETERS MEASURED: immobilisation after 24 and 48 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: ca. 2
- Range finding study: yes
- Test concentrations: 0.1, 1, 10, 100, 1000 mg/L - Reference substance (positive control):
- yes
- Remarks:
- Potassiumdichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 91 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 170 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: none
- Results with reference substance (positive control):
- EC50 (24 h) = 1.2 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the Category Approach Justification provided in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 91 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 170 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
Referenceopen allclose all
Description of key information
EC50 (48 h) for Daphnia magna = 91 mg a.i./L (nominal, DIN 38412, part II)
Key value for chemical safety assessment
Additional information
The assessment is based on the data currently available. New studies, based on the category review and the final decisions issued for some of the category substances, which are also relevant for this assessment, are currently being conducted. The hazard assessment with respect to aquatic toxicity will be updated once all ongoing studies have been finalised.
No acute invertebrates studies on toxic effects of AES (C10 -12, 1 -2.5EO) Na (CAS 68610 -66 -2) are available. Therefore, a read-across approach from the structural comparable AES (C8 -10, 2.5EO) Na was applied.
This study was performed according to DIN 38412, part II for AES (C8 -10, 1 -2.5EO) Na. Under static conditions an EC50 (48 h) value of 91 mg a.i./L (nominal) for Daphnia magna was determined (Z&S, 1992).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
