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Diss Factsheets

Physical & Chemical properties

Vapour pressure

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline compliant study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Principles of method if other than guideline:
An estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23 March 2006, Vapour Pressure” ANNEX Estimation Method newest version (Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used. This method is applied for vapour pressures between 10^3 to 10^-7 mbar. This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

This method uses the melting and the boiling temperatures.
GLP compliance:
no
Type of method:
other: stimation procedure in accordance with the test method OECD Guideline
Key result
Temp.:
20 °C
Vapour pressure:
<= 0.28 Pa
Remarks on result:
other: Calculated value
Transition / decomposition:
yes
Transition temp.:
>= 164 °C
Executive summary:

In the non-GLP Klimisch 1 study from Kintrup (2012) an estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23 March 2006, Vapour Pressure” ANNEX Estimation Method newest version (Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used for the calculation of the vapour pressure. This method is applied for vapour pressures between 10^3 to 10^-7 mbar. This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

Using a melting point of 164°C and a boiling point of 229 °C (both values might be underestimations due to decomposition) resulted in a finding that the test item has a vapour pressure of ≤ 0.28 Pa according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

This value is considered reliable for the further risk assessment.

Description of key information

Key value for chemical safety assessment

Vapour pressure:
0.28 Pa
at the temperature of:
20 °C

Additional information

In the non-GLP Klimisch 1 study from Kintrup (2012) an estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23 March 2006, Vapour Pressure” ANNEX Estimation Method newest version (Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used for the calculation of the vapour pressure. This method is applied for vapour pressures between 10^3 to 10^-7 mbar. This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

Using a melting point of 164°C and a boiling point of 229 °C (both values might be underestimations due to decomposition) resulted in a finding that the test item has a vapour pressure of ≤ 0.28 Pa according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

This value is considered reliable for the further risk assessment.