Registration Dossier
Registration Dossier
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EC number: 442-490-2 | CAS number: 871-70-5 EMEROX 118
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,18-octadecanedioic acid
- EC Number:
- 442-490-2
- EC Name:
- 1,18-octadecanedioic acid
- Cas Number:
- 871-70-5
- Molecular formula:
- C18H34O4
- IUPAC Name:
- octadecanedioic acid
- Reference substance name:
- Octadecanedioic acid
- EC Number:
- 617-978-5
- IUPAC Name:
- Octadecanedioic acid
- Test material form:
- solid: flakes
- Details on test material:
- Purity: 100% active matter
Remarks: White, solid.
Solubility: Poorly soluble (=< 2 mg/L in test medium).
Carbon chain length distribution: C16 2,98%, C18 92,9%, C18:1 1,04%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: sesame´oil
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The dermal LD50 for the test substance 1,18-octadecanedioic acid was > 5000 mg/kg bw.
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