Registration Dossier
Registration Dossier
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EC number: 246-240-1 | CAS number: 24424-99-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: read across
- GLP compliance:
- not specified
- Species:
- rabbit
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 1.74
- Max. score:
- 8
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
See attached OECD Toolbox study for skin irritation/corrosion
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: acute inhalation toxicity
- GLP compliance:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Vehicle:
- other: vapour
- Amount / concentration applied:
- 80/120/180 mg/m3
- Duration of treatment / exposure:
- 4h
- Observation period (in vivo):
- 14d
- Number of animals or in vitro replicates:
- 30
- Irritation parameter:
- other: number of rats with corneal opacity as percentage of total in the two highest dose groups (120 and 180 mg/m3/4h)
- Basis:
- mean
- Time point:
- other: 6 days
- Score:
- 30
- Max. score:
- 100
- Reversibility:
- not reversible
- Remarks on result:
- other: No corneal opacity was seen in the lowest dose group at 80 mg/m3/4h
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
See attached full study report
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
With a primary dermal irritation of 1.74 (max 8) the substance must be classified as a skin irritant category 2 (with H315: causes skin irritation).
With irreversible effects observed on the eye the substance must be classified for eye damage category 1 (with H318: causes serious eye damage)
Based on the conservative principle the substance must be classified as STOT SE category 3 (with H335: may cause respiratory irritation)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
