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EC number: 211-067-2 | CAS number: 629-03-8
Materials and Methods:
A single dose of 0.5 ml of the undiluted test substance was prepared on a dry dressing and then applied on a 6 cm2 clipped area of skin of 1 then 2 male New Zealand rabbits. The test substance was held in contact with the skin for 4 hours by a semi-occlusive dressi ng. The cutaneous reactions were observed 1 hour, 24, 48 and 72 hours after removal of the dressing. The test substance was not rinsed off after removal of the dressing. The interpretation of results was carried out according to the classification criteria laid down in the EEC Directive 83/467/EEC, Commission dated 29th July 1983, according to the fifth adaptation of the technical progress council 67/548 / EEC.
One hour after the removal of the dressing, a very slight erythema (score of 1 in animal 1) or/ and well-defined (score of 2 in animal 1) were observed. No oedema was noted. After 24 hours, the erythema was very slight in animal 1 and well - defined in 2 animals. After 48 hours, the erytnema was very slight in 3 animals. No cutaneous reactions were noted after 72 hours. According to this results the substance is not classified as skin irritant according the the criteria of Regulation EC 1272/2008 and amendments.
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