Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-067-2 | CAS number: 629-03-8
Materials and Methods
In a first assay, the test substance was administered by oral route to a group of 10 fasted Sprague-Dawley rats (5 males and 5 females) . The test item was administered undiluted at a dose level of 2000 mg/kg taking i nto consideration the density of the test substance (d =1.6). In a second assay the test substance was administered to a group of 10 rats at a dose level of
There was no mortality at the dose level of 200 mg/kg and the mortalfty rate was 60% after 5 days at the dose level of 2000 mg/kg. The clinical signs observed consisted in a reduction of the spontaneous activity and piloerection in the 4 hours following the administration of the test substance at 200 mg/kg or during 4 days at 2000 mg/kg. The bodyweight gain of the animals was not influenced by the treatment at 200 mg/kg and was reduced until D 5 at 2000 mg/kg and remained normal thereafter. The macroscopic examination of all the animals found dead during the study or sacrificed at the end of the study revealed no abnormality .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again