Registration Dossier

Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data collected from modelling - US EPA Tool - BCFBAF v.3.01

Data source

Reference
Reference Type:
other: Modelling - EpiSuite v4.1 - US EPA Tool - BCFBAF v.3.01
Title:
Unnamed
Report Date:
2012

Materials and methods

Principles of method if other than guideline:
EPI Suite™ is a screening-level predictive tool based on SMILE notation.  The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. Moreover, the intended application domain of EPI Suite is organic chemicals which is in line with the test item.

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
194.9 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Log BCF = 2.290
Type:
BCF
Value:
192.4 L/kg
Basis:
whole body w.w.
Calculation basis:
other: Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for upper trophic level.
Type:
BAF
Value:
192.5 L/kg
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for upper trophic level.
Type:
BCF
Value:
217.2 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for mid trophic level.
Type:
BAF
Value:
218 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for mid trophic level.
Type:
BCF
Value:
220.1 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for lower trophic level.
Type:
BAF
Value:
224.7 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling including biotransformation rate estimates for lower trophic level.
Type:
BCF
Value:
2 990 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling assuming a biotransformation rate of zero for upper trophic level.
Type:
BAF
Value:
3 335 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Remarks:
Modelling - BCFBAF V3.01 - US EPA tool - Estimation methodology
Remarks on result:
other: Arnot-Gobas modelling assuming a biotransformation rate of zero for upper trophic level.

Applicant's summary and conclusion

Conclusions:
No testing is currently available to assess the bioaccumation in living organisms. However, the log Kow estimate (logKow = 3.8) indicates that the substance may bioaccumulate to a significant degree (Guidance on information requirements, ECHA, Chapter R7c, pp23). Nevertheless, when running modelisation (BCFBAF v3.01 - US EPA tool), it seems that the registered substance does not bioaccumate into organisms when the biotransformation rate in fish is considered. However, no further details are currently available on the registered substance metabolization.