Registration Dossier
Registration Dossier
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EC number: 223-989-2 | CAS number: 4156-21-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1973
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: unclear, confusing information on chamber concentration; actual dose is undefined (see below)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Sec. IV. Inhalation ; from: Principles and Procedures for Evaluating the Toxicity of Household Substances; Publication 1138, Nat. Academy of Sciences - Nat. Res. Council; Washington DC, USA 1964
- Principles of method if other than guideline:
- Animals were exposed for 1 hour and afterwards observed regularly for 14 days. Parameters were: Mortality, clinical signs, weight gain,
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate
- EC Number:
- 223-989-2
- EC Name:
- Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate
- Cas Number:
- 4156-21-2
- Molecular formula:
- C9H6Cl2N4O3S.Na
- IUPAC Name:
- sodium 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulfonate
- Details on test material:
- fine clorless powder
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Animals were exposed for 1 hour and observed for 14 days afterwards.
Chamber size: 135 L for a simultaneous exposure of all animals. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Particle size and count. There is no information regarding the mass distribution over the range of particle sizes. Thus the inhalable dose is unknown.
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 200 mg/L air or 200 ppm (Both statements are in the report. It is not clear which is true! The respirable fraction is not known)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
- Mortality:
- none
- Clinical signs:
- other: none
- Body weight:
- no effects
- Gross pathology:
- reddish lungs in 3 males and 1 female of a total of 10 animals
in 1 male both kidneys showed a "cavitation"
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
