Registration Dossier
Registration Dossier
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EC number: 248-502-0 | CAS number: 27503-81-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2.8.2011 - 4.11.2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.038
- Temp.:
- 25 °C
- pH:
- >= 4.14 - <= 4.16
- Remarks on result:
- other: the pH is given for the aqueous phase, resulting from 5 independant measurements
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.42
- Temp.:
- 25 °C
- pH:
- >= 4.14 - <= 4.16
- Remarks on result:
- other: the pH is given for the aqueous phase, resulting from 5 independant measurements
- Details on results:
- The octanol solubility of test substance was determined to be 4.1 mg/L, and the water solubility was 109 mg/L. So Pow=4.1/109=0.03761, and logP = -1.42.
- Conclusions:
- The partition coefficinet of the test item was determined to be -1.42 (25 °C).
Reference
Description of key information
The partition coefficinet of the test item was determined to be -1.42 (25 °C).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.42
- at the temperature of:
- 25 °C
Additional information
The partition coefficient was estimated by determination of the solubility of test substance in water and octanol separately (the water solubility was tested and reported using shake flask method independently, which is 109 mg/L at 25 °C). The octanol solubility was determined to be 4.1 mg/L in this test, thus, the logPow is estimated to be -1.42, indicating the test substance is far more soluble in water than in octanol.
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