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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

In five reliable studies (3x RL 1, 2x RL 2) with different members of the DMA category, determined EC50 (3 h) values were between 53.1 µM (C12-18-DMA; RL 1) and 363.0 µM (C12-14-DMA; RL 2).

Key value for chemical safety assessment

EC50 for microorganisms:
13 mg/L

Additional information

Reliable (RL 1 for C10, C12-18, and C16-18-DMA; RL 2 for C12-14 and C16-DMA) Activated Sludge Respiration Inhibition tests were performed according to OECD 209 meeting the validity criteria of the OECD-guideline. RL 1 studies are GLP-compliant. The resulting EC50 (3 h) values were 175.8 µM for C10, 363.0 µM for C12-14, 148.4 µM for C16, 53.1 µM for C12-18 and 131.9 µM for C16-18-DMA. Further, three non-reliable studies (RL 3) are available reporting EC50 values between >3360 µM for C18-DMA and 127.9 µM for C12-DMA. In most studies, EC10 values could not be determined. No obvious relationship between chain length and toxicity exists.


Thus, the decisive value for derivation of a PNEC_STP microorganisms for the DMA category will be EC50 (3 h) determined with C12-18-DMA of 53.1 µM (13 mg/L). The mass concentration of C12-18-DMA is used as the key value for hazard and risk assessment, because a) molar concentrations cannot be used for environmental hazard and risk assessment and b) correction for MW would theoretically result in somewhat lower values for shorter chain DMAs, but the available reliable EC50 (3h) values for C10-DMA and C12-14-DMA are considerably higher (32.6 mg/L and 80 mg/L, respectively).