Registration Dossier
Registration Dossier
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EC number: 203-372-4 | CAS number: 106-20-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets standard scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data, List III
- Author:
- Smyth H.F. et al.
- Year:
- 1 949
- Bibliographic source:
- J.Ind.Hyg.Toxicol. 31, 60-61
- Reference Type:
- publication
- Title:
- The place of the range finding test in the industrial toxicology laboratory
- Author:
- Smyth H.F. and Carpenter C.P.
- Year:
- 1 944
- Bibliographic source:
- J.Ind.Hyg.Toxicol., 26, 269-273
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical, as detailed by Carpenter and Smyth. 24 h after instillation the eyes were observed for gross evidence of injury. Grade 1 indicates at most a very small area of necrosis resulting from 0.5 mL of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 mL, and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl)amine
- EC Number:
- 203-372-4
- EC Name:
- Bis(2-ethylhexyl)amine
- Cas Number:
- 106-20-7
- Molecular formula:
- C16H35N
- IUPAC Name:
- bis(2-ethylhexyl)amine
- Details on test material:
- - Name of test material (as cited in study report): Di(2-ethylhexyl)amine
no further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- other: eye injury
- Basis:
- other: no data
- Time point:
- 24 h
- Score:
- 8
- Max. score:
- 10
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The application of the test substance caused serious damage to the exposed eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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