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EC number: 290-836-4
CAS number: 90268-36-3
After 21 days 0, 0, 0, 0, 10 and 60%
mortality was observed in the control and at nominal test concentrations
of 0.1375, 0.275, 0.55, 1.1 and 2.2 mg/L, respectively.
The reproduction per parent daphina
was 124.6 (10), 145.6 (10), 126.9 (10), 131.7 (10), 127.0 (10), and 98.6
(10) living offspring per parental animal
(number of parental daphinds used to
calculate the mean are given in brackets) in the control and 0.1375,
0.275, 0.55, 1.1 and 2.2 mg/L, respectively
Summary of the results after 21 days
of exposure of the test animals
Nominal test item concentrations[mg/L]
Mortality [%] after 21 days of exposure
Mean reproduction rate (living offspring per adult)
Mean reproduction rate in % of control
Mean body length of the adults [mm]
Mean body length of the adults in % of control
The biological results can be
summarized as follows (on the basis of nominal concentrations of the
Inhibition of reproduction rate
Inhibition of growth
95% confidence interval
0.38 - 1.86
0.27 – 1.49
n.d.: could not be determined, due to
lack of inhibitory effects
Klimisch 1 GLP study from Eckenstein (2015) the chronic toxicity of
Sulfosuccinic (FA C12-18)E, 2Na on Daphnia magna was determined in an 21
day semi-static test according to OECD 211. The test was performed with
concentrations of 0.1375, 0.275,
0.55, 1.1, and 2.2 mg Sulfosuccinic (FA C12-18)E, 2Na /L and a blank
control. Ten replicates with 1 Daphnia each were set up. After 21 days
0, 0, 0, 0, 10, 60 and 100% mortality was observed in the control and at
nominal test concentrations of 0.1375, 0.275,
0.55, 1.1, and 2.2 mg Sulfosuccinic (FA C12-18)E, 2Na /L, respectively.
reproduction per parent daphina was 124.6 (10), 145.6 (10), 126.9 (10),
131.7 (10), 127.0 (10), and 98.6 (10) living offspring per parental
animal (number of parental daphinds used to calculate the mean are given
in brackets) in the control and 0.1375, 0.275, 0.55, 1.1 and 2.2 mg/L,
biologically relevant dose groups, the measured test item concentrations
in the freshly prepared test media of the nominal concentrations of 0.55
to 2.2 mg/L were between 89 and 112% of the nominal values at the start
of the test medium renewal periods. In the aged test media samples
without food, the measured concentrations as % nominal were between 83
and 104%. Therefore, the biological results were based on nominal
for mortality is 1.1 mg/L, the EC10 for reproduction is 1.6 mg/L. Length
was not affected. For the risk assessment, the more conservative EC10,
i.e., the EC10 for mortality was used.
is considered relevant and reliable for the risk assessment.
21-day EC10: 1.1 mg/L
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