N-isopropylmethacrylamide

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Starting Date: 17 May 2012, Experimental Completion Date: 03 July 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

no

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Melting / freezing pt.:

77 - 92 °C

Atm. press.:

101.6 kPa

Decomposition:

no

Sublimation:

no

Results

    

The temperatures shown in the following tables are those of the liquid bath (T_D), the emergent stem (T_E) and the corrected temperature (T).

 

Table 3.1       Determination 1

TD(°C)	TE(°C)	T (°C)	T (K)	Observations
22	20	22	295	Test item is a fine yellow crystalline powder
37	23	37	310	No change
48	28	48	321	No change
52	31	52	325	No change
60	34	60	334	No change
73	41	74	347	Test item is a pale yellow solid
79	44	80	353	Test item has slightly shrunk
82	46	83	356	Test item is a pale yellow solid
86	49	87	360	Test item is shrinking
88	50	89	362	Test item is collapsing
90	51	91	364	Test item is liquefying and amber in color
91	51	92	365	Test item is an amber liquid. End of test

 

Result:            melting range: 80 to 92 °C (353 to 365 K)

Table 3.2       Determination 2

TD(°C)	TE(°C)	T (°C)	T (K)	Observations
28	26	28	301	Test item is a fine yellow crystalline powder
35	27	35	308	No change
50	30	50	323	No change
63	35	63	337	No change
76	39	77	350	Test item is a slightly shrunken, pale yellow solid
86	41	87	360	Test item is shrinking
88	42	89	362	Test item is collapsing
90	42	91	364	Test item is liquefying and amber in color
91	43	92	365	Test item is an amber liquid. End of test

 

Result:           melting range: 77 to 92 °C (350 to 365 K)

 

Overall result: melting range: 77 to 92 °C (350 to 365 K)

 

Atmospheric pressure:101.6 kPa

Conclusions:

The melting temperature was determined to be over the range 77 to 92 °C (350 to 365 K).

Executive summary:

Melting Point

Method

The determination was carried out using the capillary method with liquid bath, using a procedure designed to be compatible with Method A1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The test item is placed in a glass capillary tube and is slowly heated under equilibrium conditions at atmospheric pressure until melting occurs or until a temperature of at least 360 °C is reached.

Conclusion

The melting temperature was determined to be over the range 77 to 92 °C (350 to 365 K).

Description of key information

The melting temperature was determined to be over the range 77 to 92 °C (350 to 365 K).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

77 °C

Additional information

The determination was carried out using the capillary method with liquid bath, using a procedure designed to be compatible with Method A1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The test item is placed in a glass capillary tube and is slowly heated under equilibrium conditions at atmospheric pressure until melting occurs or until a temperature of at least 360 °C is reached.

The melting temperature was determined to be over the range 77 to 92 °C (350 to 365 K).