Registration Dossier
Registration Dossier
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EC number: 700-539-8 | CAS number: 175481-26-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- (R)-2-acetamido-N-benzyl-3-methoxypropionamide
- EC Number:
- 605-756-0
- Cas Number:
- 175481-36-4
- Molecular formula:
- C13H18N2O3
- IUPAC Name:
- (R)-2-acetamido-N-benzyl-3-methoxypropionamide
- Test material form:
- other: Solid, powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Not discribed
- Details on exposure:
- single intraperitoneal injection
- Duration of treatment / exposure:
- single injection
- Frequency of treatment:
- single injection
- Post exposure period:
- 3 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 mg/kg bw/day
- Dose / conc.:
- 100 mg/kg bw/day
- Dose / conc.:
- 200 mg/kg bw/day
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Substance did not induce a significant increase in the incidence of micronucleated polychomatic erythrocytes in bone marrow and was concluded to be negative in the micronucleus test using male and female ICR mice
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