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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13-18 April, 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD TG 105
Deviations:
yes
Remarks:
n-octanol used in place of water
GLP compliance:
yes (incl. QA statement)
Medium:
n-octanol
Solubility:
7.43 g/L
Temp.:
20 °C

Substance concentration of the n-octanol samples after 1, 2 & 3 days equilibration:

Equilibration time

Test Item (mg/mL)

Mean (mg/mL)

RSD%

1 day

5.54

5.61

5.99

5.30

5.97

2 days

6.98

7.10

1.68

7.11

7.22

3 days

7.95

7.75

2.75

7.52

7.77

Description of key information

The solubility in n-octanol is 7.43 g/L at 20 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
7.43 g/L

Additional information

The solubility in n-octanol was measured using the method described in OECD TG 105 under GLP. The solubility was found to be 7.43 g/L at 20 °C.