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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
BASF-Test: 5 rats per group per sex were intraperitoneally administered different doses of the test substance. Animals were observed for clinical signs for 14 days and necropsy was performed on surviving animals as well as on animals that died during the observation period.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Tetramethylpropandiamin-1,3
- Analytical purity: 99 %
- Physical state: liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Dr. Thomae GmbH, Biberach, Germany
- Age at study initiation: ca. 12 weeks
- Mean weight at study initiation: 197 g (males); 183 g (females)
- Fasting period before study: 16 h
- Housing: 5 per cage; V-II-A cages, type DK-III (Fa. Becker & Co, Castrop Rauxel)
- Diet: Ssniff R
- Water: ad libitum
- Acclimation period: at least 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26 °C
- Humidity (%): 45 - 75
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
50, 100 and 215 mg/kg bw (0.5, 1.0 and 2.15% respectively)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 83.2 mg/kg bw
Based on:
test mat.
Remarks on result:
other: based on interpolation
Mortality:
50 mg/kg bw: 0/10 animals died
100 mg/kg bw: 6/10 animals died
215 mg/kg bw: 10/10 animals died

Applicant's summary and conclusion