Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 234-974-5 | CAS number: 12047-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Barium hexaferrite shares common functional groups with iron oxides.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
No purity information is available (data from secondary source).
3. ANALOGUE APPROACH JUSTIFICATION
Both barium hexaferrite and iron oxides are water insoluble, powdered substances. In contact with eyes, in the clinical experience they behave similarly.
4. DATA MATRIX
Data drom secondary source. Detailed information is not avalilable.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Hazardtext - Iron oxide
- Author:
- TOMES System
- Year:
- 2 010
- Bibliographic source:
- TOMES System (electronic version). Thomson Reuters, Greenwood Village, Colorado, USA. Edition 2010.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- observation after clinical and practical experience
- GLP compliance:
- no
Test material
- Reference substance name:
- Iron oxide
- IUPAC Name:
- Iron oxide
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: clinical observations
- Remarks:
- clinical observations
- Time point:
- other: not declared
- Remarks on result:
- other: Iron oxides would be expected to be an eye irritant from frictional action.
Any other information on results incl. tables
Iron oxides would be expected to be an eye irritant from frictional action.
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating effect related to frictional action
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Barium hexaferrite powder may have eye irritating effects due to frictional action.
- Executive summary:
Barium hexaferrite powder may have eye irritating effects due to frictional action.
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