Registration Dossier
Registration Dossier
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EC number: 234-974-5 | CAS number: 12047-11-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Barium hexaferrite shares common functional groups with iron oxides.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
No purity information is available (data from secondary source).
3. ANALOGUE APPROACH JUSTIFICATION
Both barium hexaferrite and iron oxides are water insoluble, powdered substances. In contact with eyes, in the clinical experience they behave similarly.
4. DATA MATRIX
Data drom secondary source. Detailed information is not avalilable.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Hazardtext - Iron oxide
- Author:
- TOMES System
- Year:
- 2 010
- Bibliographic source:
- TOMES System (electronic version). Thomson Reuters, Greenwood Village, Colorado, USA. Edition 2010.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- observation after clinical and practical experience
- GLP compliance:
- no
Test material
- Reference substance name:
- Iron oxide
- IUPAC Name:
- Iron oxide
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: clinical observations
- Remarks:
- clinical observations
- Time point:
- other: not declared
- Remarks on result:
- other: Iron oxides would be expected to be an eye irritant from frictional action.
Any other information on results incl. tables
Iron oxides would be expected to be an eye irritant from frictional action.
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating effect related to frictional action
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Barium hexaferrite powder may have eye irritating effects due to frictional action.
- Executive summary:
Barium hexaferrite powder may have eye irritating effects due to frictional action.
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