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EC number: 234-961-4 | CAS number: 12045-63-5
An acute inhalation toxicity test was conducted with rats to determine the potential for Titanium Diboride to produce toxicity from a 4-hour exposure via the inhalation (nose-only exposure) route. Under the conditions of this study, the single exposure acute inhalation LC50 of the test substance is greater than 5.05mg/L in male and female rats. Based on the results of this study, Titanium Diboride has no labeling requirements for acute inhalation toxicity and is not classified.
After establishing the desired generation procedures during pre-test trials, ten healthy rats (5/sex) were exposed to the test atmosphere for 4 hours. Chamber concentration and particle size distributions of the test substance were determined periodically during the exposure period. The animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days following exposure. Body weights were recorded prior to exposure and again on Days 1, 3, 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice.
The gravimetric chamber concentration was 5.05mg/L. Based on graphic analysis of the particle size distribution as measured with an ACFM Andersen Ambient Particle Sizing Sampler, the mass median aerodynamic diameter was estimated to be 3.5.
All animals survived exposure to the test atmosphere. Following exposure, all animals exhibited abnormal respiration. However, the animals recovered from this symptom by Day 6 and appeared active and healthy for the remainder of the 14-day observation period. Although all animals lost body weight by Day 1 and/or Day 3, all animals showed a continued weight gain thereafter through Day 14. No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
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