16α,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acute aquatic toxocity has been obtained by read-across method from category members using the OECD Toolbox v.3.1.

Data source

Reference

Reference Type:

other: software

Title:

QSAR Toolbox 3.1.0.21

Author:

OECD

Year:

2013

Bibliographic source:

http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:

Read-across from category members

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Androst-4-ene-3,17-dione

EC Number:

200-554-5

EC Name:

Androst-4-ene-3,17-dione

Cas Number:

63-05-8

IUPAC Name:

androst-4-ene-3,17-dione

Constituent 2

Reference substance name:

Betamethasone

EC Number:

206-825-4

EC Name:

Betamethasone

Cas Number:

378-44-9

IUPAC Name:

9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Constituent 3

Reference substance name:

Prednisolone

EC Number:

200-021-7

EC Name:

Prednisolone

Cas Number:

50-24-8

IUPAC Name:

11,17,21-trihydroxypregna-1,4-diene-3,20-dione

Constituent 4

Reference substance name:

5571-36-8

EC Number:

611-306-4

Cas Number:

5571-36-8

IUPAC Name:

5571-36-8

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:

static

Results and discussion

Effect concentrations

Dose descriptor:

EC50

Effect conc.:

27.1 mg/L

Remarks on result:

other: Calculated by OECD Toolbox v.3.1

Any other information on results incl. tables

Toxicity of the target chemical (27.1 mg/L) is predicted from category members using read-across based on 4 values within the range 3.75 - 160 mg/L from 4 nearest neighbours compared by prediction descriptors. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical.

Read-across from category members.

The target chemical FALLS within applicability domain.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

A EC50 of 27.1 mg/L Pseudokirchnerella subcapitata has been predicted.