Registration Dossier
Registration Dossier
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EC number: 278-593-2 | CAS number: 77017-20-0
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acute aquatic toxocity has been obtained by read-across method from category members using the OECD Toolbox v.3.1.
Data source
Reference
- Reference Type:
- other: software
- Title:
- QSAR Toolbox 3.1.0.21
- Author:
- OECD
- Year:
- 2 013
- Bibliographic source:
- http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm
Materials and methods
- Principles of method if other than guideline:
- Read-across from category members
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (2β,3β,5β,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
- EC Number:
- 222-760-4
- EC Name:
- (2β,3β,5β,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
- Cas Number:
- 3604-87-3
- IUPAC Name:
- 2,3,14,22,25-pentahydroxycholest-7-en-6-one
- Reference substance name:
- Hydrocortisone 21-acetate
- EC Number:
- 200-004-4
- EC Name:
- Hydrocortisone 21-acetate
- Cas Number:
- 50-03-3
- IUPAC Name:
- 11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
- Reference substance name:
- 13408-56-5
- Cas Number:
- 13408-56-5
- IUPAC Name:
- 13408-56-5
- Reference substance name:
- Fluocortolone
- EC Number:
- 205-811-5
- EC Name:
- Fluocortolone
- Cas Number:
- 152-97-6
- IUPAC Name:
- 6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
- Reference substance name:
- Ethisterone
- EC Number:
- 207-096-5
- EC Name:
- Ethisterone
- Cas Number:
- 434-03-7
- IUPAC Name:
- 17-hydroxypregn-4-en-20-yn-3-one
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Test organisms
- Test organisms (species):
- Daphnia magna
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.43 mg/L
- Remarks on result:
- other: Calculated by OECD Toolbox v.3.1
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- An acute aquatic toxicity value LC50 48 hour(s) on Daphnia magna 4,43 mg/L has been obtained by a reliable and scientifically adequate model.
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