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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acute aquatic toxocity has been obtained by read-across method from category members using the OECD Toolbox v.3.1.

Data source

Reference
Reference Type:
other: software
Title:
QSAR Toolbox 3.1.0.21
Author:
OECD
Year:
2013
Bibliographic source:
http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:
Read-across from category members
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
(2β,3β,5β,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
EC Number:
222-760-4
EC Name:
(2β,3β,5β,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
Cas Number:
3604-87-3
IUPAC Name:
2,3,14,22,25-pentahydroxycholest-7-en-6-one
Constituent 2
Reference substance name:
Hydrocortisone 21-acetate
EC Number:
200-004-4
EC Name:
Hydrocortisone 21-acetate
Cas Number:
50-03-3
IUPAC Name:
11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
Constituent 3
Reference substance name:
13408-56-5
Cas Number:
13408-56-5
IUPAC Name:
13408-56-5
Constituent 4
Reference substance name:
Fluocortolone
EC Number:
205-811-5
EC Name:
Fluocortolone
Cas Number:
152-97-6
IUPAC Name:
6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Constituent 5
Reference substance name:
Ethisterone
EC Number:
207-096-5
EC Name:
Ethisterone
Cas Number:
434-03-7
IUPAC Name:
17-hydroxypregn-4-en-20-yn-3-one

Test organisms

Test organisms (species):
Daphnia magna

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
4.43 mg/L
Remarks on result:
other: Calculated by OECD Toolbox v.3.1

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
An acute aquatic toxicity value LC50 48 hour(s) on Daphnia magna 4,43 mg/L has been obtained by a reliable and scientifically adequate model.