Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
auto-flammability
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Value obtained by Read-across from category member using the OECD Toolbox v.3.1.

Data source

Reference
Reference Type:
other: software
Title:
QSAR Toolbox 3.1.0.21
Author:
OECD
Year:
2013
Bibliographic source:
http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:
Read-across approach made by OECD Toolbox v.3.1

Test material

Constituent 1
Reference substance name:
Prednisolone
EC Number:
200-021-7
EC Name:
Prednisolone
Cas Number:
50-24-8
IUPAC Name:
11,17,21-trihydroxypregna-1,4-diene-3,20-dione
Constituent 2
Reference substance name:
C(=O)(C1(O)C2(C)C(C3C(C4(C)C(=CC(=O)C=C4)CC3)C(O)C2)CC1)CO
IUPAC Name:
C(=O)(C1(O)C2(C)C(C3C(C4(C)C(=CC(=O)C=C4)CC3)C(O)C2)CC1)CO

Results and discussion

Auto-ignition temperature (liquids / gases)
Auto-ignition temperature:
357 °C
Atm. press.:
760 mm Hg
Remarks on result:
other: Stimated by OECD Toolbox
Relative self-ignition temperature (solids)
Relative self-ignition temperature:
357 °C
Remarks on result:
other: Stimated by OECD Toolbox
Remarks:
at atm. press. of 760.0 mm Hg

Any other information on results incl. tables

Autoflammability of the target chemical (357 °C) is predicted from category member using read-across from 1 nearest neighbours compared by prediction descriptors.

Applicant's summary and conclusion

Conclusions:
Autoflammability has been estimated by read-across to be 357°C.