16α,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

Auto flammability

Administrative data

Endpoint:

auto-flammability

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Value obtained by Read-across from category member using the OECD Toolbox v.3.1.

Data source

Reference

Reference Type:

other: software

Title:

QSAR Toolbox 3.1.0.21

Author:

OECD

Year:

2013

Bibliographic source:

http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:

Read-across approach made by OECD Toolbox v.3.1

Test material

Test material information

Constituent 1

Reference substance name:

Prednisolone

EC Number:

200-021-7

EC Name:

Prednisolone

Cas Number:

50-24-8

IUPAC Name:

11,17,21-trihydroxypregna-1,4-diene-3,20-dione

Constituent 2

Reference substance name:

C(=O)(C1(O)C2(C)C(C3C(C4(C)C(=CC(=O)C=C4)CC3)C(O)C2)CC1)CO

IUPAC Name:

C(=O)(C1(O)C2(C)C(C3C(C4(C)C(=CC(=O)C=C4)CC3)C(O)C2)CC1)CO

Results and discussion

Auto-ignition temperature (liquids / gases)

Auto-ignition temperature:

357 °C

Atm. press.:

760 mm Hg

Remarks on result:

other: Stimated by OECD Toolbox

Relative self-ignition temperature (solids)

Relative self-ignition temperature:

357 °C

Remarks on result:

other: Stimated by OECD Toolbox

Remarks:

at atm. press. of 760.0 mm Hg

Any other information on results incl. tables

Autoflammability of the target chemical (357 °C) is predicted from category member using read-across from 1 nearest neighbours compared by prediction descriptors.

Applicant's summary and conclusion

Conclusions:

Autoflammability has been estimated by read-across to be 357°C.