3-(triethoxysilyl)propanethiol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-(triethoxysilyl)propanethiol

EC Number:

238-883-1

EC Name:

3-(triethoxysilyl)propanethiol

Cas Number:

14814-09-6

Molecular formula:

C9H22O3SSi

IUPAC Name:

3-(triethoxysilyl)propane-1-thiol

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Carnegie-Mellon Institute of Research
- Age at study initiation: 3-5 months
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: the trunk
- Type of wrap if used: 'impervious sheeting'

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): maximum dose that can be retained is 16 to 20 ml/kg bw

Duration of exposure:

24 h

Doses:

16, 8, 4, 2, 1 ml/kg bw

No. of animals per sex per dose:

2M (16 ml/kg bw), 4M (8 ml/kg bw), 4M (4 ml/kg bw), 4M (2 ml/kg bw), 4M (1 ml/kg bw)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Statistics:

Not specified

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

2.52 mL/kg bw

Based on:

test mat.

95% CL:

ca. 1 - ca. 6.33

Effect levels 2

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

2 500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Based on specific gravity 0.98 g/cm3

Mortality:

2/2 (16 ml/kg bw), 4/4 (8 ml/kg bw), 2/4 (4 ml/kg bw), 2/4 (2 ml/kg bw), 1/4 (1 ml/kg bw)

Clinical signs:

other: Two prostrate at 'one day' (8 and 4 ml/kg bw), one prostrate at 'one day' (2 ml/kg bw). Erythema, ecchymosis, scabs, desquamation at application site, depending on dose.

Gross pathology:

In victims, livers were paled and mottled, spleens dark, kidneys congested. Nothing remarkable in survivors.

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Remarks:

Not classified according to Regulation (EC) No. 1272/2008

Conclusions:

In a study pre-dating GLP but conducted according to a protocol equivalent or similar to OECD Test Guideline 402 (reliability score 1), the acute dermal LD50 for 3-(triethoxysilyl)propanethiol in the male albino rabbit was 2.52 ml/kg bw (approximately 2500 mg/kg bw).