Registration Dossier
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EC number: 214-277-2 | CAS number: 1119-40-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour LC50 of DMG is estimated to be greater than 112 ppm (v/v) but less than 150 ppm (v/v).
Key value for chemical safety assessment
Additional information
No studies were available for dimethyl gluatarte for this endpoint. Therefore, evaluation is based on read-across to a structurally similar substance, DBE (EC# 906 -170 -0). Two reliable studies are available for this endpoint. In the key study ( Phillips FX, 1982)Daphnids (Daphnia magna) were exposed to Dibasic esters (DBE) with the test medium. No mass based concentrations or density is given in the study report. No GLP statement is made. The protocol applied is comparable to EPA OTS 797.1300 (Fish Acute Toxicity Test). The study is however considered valid and conclusive since the density of the test item is considered not different from standard material.
The test animals were exposed to nominal concentrations of 0, 20, 27, 36, 47, 63, 84, 112, 150, and 200 ppm(v/v). No analytical measurements of the tested concentrations was performed but due to the high solubility of the substance it is expected to be stable during the test.
No mortality was observed in the control. The temperature and the oxygen in the medium were maintained in the range recommended by the guidance document. The test item, DBE, exhibited slight acute toxicity to daphnids (Daphnia magna) under static, unaeriated test conditions during a 48-hour exposure. The NOEC was at 84 ppm (v/v) and the LOEC at 112 ppm (v/v), where 25% mortality was observed. Thus the 48-hour LC50is estimated to be greater than 112 ppm (v/v) but less than 150 ppm (v/v) in laboratory-aged well water.
The second study (Gard A, 1990) has been selected as supporting study as it has been performed with only 24h of exposure, but showed a 24hEC50 above 100 mg/L.
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