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EC number: 500-464-9
CAS number: 160901-27-9
1 - 2.5 moles ethoxylated
Although no specific carcinogenicity study is available on alkyl ether sulfates (AES), the scientific weight of the evidence suggests that members of the AES category do not cause carcinogenic effects. This expert judgment takes account of the complete absence of genotoxicity and structural alerts for genotoxicity and carcinogenicity for all members of AES category as well as their overall low toxicity in repeated dose toxicity studies.
Based on weight of evidence members of the AES category does not
cause carcinogenicity. This endpoint is therefore considered to be
conclusive but not sufficient for classification.
The alkyl ether sulfates (AES) reported within the category show
similar structural, physico-chemical, environmental and toxicological
properties. The approach of grouping different AES for the evaluation of
their effects on human health and the environment was also made by the
Danish EPA (2001) and HERA (2003), supporting the read-across approach
between structurally related AES.
Several studies investigating the genetic toxicity of different
AES in vitro and in vivo have shown that AES are not genotoxic.
Moreover, the repeated dose toxicity tests revealed no substance-related
adverse effects indicative for carcinogenicity such as preneoplastic
lesions (e.g. hyperplasia or metaplasia). Furthermore, AES are
metabolised to physiologically occurring metabolites, which chemically
behave like in the same way as their natural counterparts. The systemic
toxicity of the compounds in this category is predicted to be very low,
based on the known properties of the predictable metabolites. Based on
this weight of evidence approach members of the AES category does not
cause carcinogenicity. In accordance to Regulation (EC) No. 1907/2006,
Annex X, 8.9.1 Column 2, testing of carcinogenicity is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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