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EC number: 619-916-2
CAS number: 12031-95-7
Lithium titanium oxide is of low acute toxicity.
An acute oral toxicity study according to the Acute Toxic Class method
was performed with rats.
The LD50oral,14d is >2000 mg/kg bw.
No relevant signs of toxicity were observed up to 2000 mg/kg bw.
The particle size distribution of the test atmosphere was as follows:
Mean Achieved (mg/L): 5.04
Mean Mass Median Aerodynamic Diameter (MMAD) (μm): 2.67
Geometric Standard Deviation: 1.92
Inhalable Fraction (% < 4μm): 73.2
The study was performed to assess the
acute inhalation toxicity of the test item. The methods used were OPPTS
870.1300, OECD 403 and EC 440/2008, B.2. A
group of ten Wistar rats (five males and five females) was exposed to an
dust atmosphere. The animals were exposed for 4 hours using a nose-only
exposure system, followed by a fourteen day observation period.
The mean achieved
mg/L. SD = 0.21.
Mean Mass Median
Aerodynamic Diameter (MMAD): 2.67 μm. SD = 1.92.
Inhalable Fraction (<
4μm): 73.2 %.
Clinical observations: Significant
clinical signs commonly noted on the day of exposure included laboured
respiration, respiratory rate increased and activity decreased. No
abnormalities were detected in all animals from Day 1 until the end of
the observation period.
Body weights: Normal
bodyweight gain was noted during the whole observation period for all
Necropsy: No gross
changes were detected.
The acute inhalation
median lethal concentration (4hr LC50) of Lithium-Titanium-Oxide, in
rats, was greater than 5.04 mg/L.
No indications were obtained to justify a classification of the
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