Registration Dossier
Registration Dossier
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EC number: 249-881-5 | CAS number: 29820-13-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD401
- Deviations:
- yes
- Remarks:
- intraperitoneal application
- Principles of method if other than guideline:
- Acute toxicity study after i.p. application in rats.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- CaTG
- IUPAC Name:
- CaTG
- Reference substance name:
- Calcium sulphidoacetate
- EC Number:
- 249-881-5
- EC Name:
- Calcium sulphidoacetate
- Cas Number:
- 29820-13-1
- Molecular formula:
- C2H4O2S.Ca x 3 H2O
- IUPAC Name:
- calcium 2-sulfanidylacetate
- Test material form:
- solid - liquid: suspension
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 64, 80, 86, 100, 125 and 140 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 98 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 68 mg/kg bw
- Based on:
- act. ingr.
- Clinical signs:
- Reduced activity, laboured breathing, dyspnoe, tremor, convulsion, prone position and tumbling
- Gross pathology:
- Findings of toxicological importance and for toxicological evaluation can be summarized as follows:
Animals sacrificed at the end of the observation period: low perihepatitis and a slight hepatomegaly.
Animals succumbing during the observation period: catarrh and gastroenteritis. - Other findings:
- First exitus after 2 hours, last exitus after 4 days.
Applicant's summary and conclusion
- Conclusions:
- Study describes possible target organs of a repeat-dose study with the active ingredient thioglycolate. Study not used for C & L.
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