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EC number: 249-881-5 | CAS number: 29820-13-1
The test item was applied to the skin of one group of ten Sprague-Dawley rats (five males and five females).
The application was performed with the test item in its original form at the dose-level of 2000 mg/kg. PEG 400 was used to moisten the gauze pad and ensure a good contact with the skin.
The test site was then covered by a semi-occlusive dressing for 24 hours.
Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test item.
All animals were subjected to necropsy.
No clinical signs and no deaths were observed during the study.
A reduced body weight gain or a slight body weight loss was seen in 2/5 females between day 8 and day 15. The overall body weight gain of the other animals was similar to that of CIT historical control animals.
Skin reactions were noted in almost all animals between day 3 and day 14 at the latest.
No apparent abnormalities were observed at necropsy in any animal.
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