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EC number: 249-881-5 | CAS number: 29820-13-1
Sodium thioglycolate (NaTG) was choosen for long-term animal studies to act as an appropriate surrogate for thioglycolic acid and its salts. Correcting the NOAEL for molecular weight is regarded as not necessary, as it has a negligible effect on this value.
Dermal, systemic effects
The available data suggests no relevant differences in dermal absorption among salts of thioglycolic acid.
Step 1) Relevant dose descriptor
NOAELMouse> 360 mg/kg bw/day
Step 2) Modification of starting point
Correction for substance differences in dermal absorption
Step 3) Assessment factors
Quality of database
2.5 x 7
> 2.06 mg/kg bw/day
(360 x 1/(2.5 x 7 x 5 x 2 x 1 x 1))
Inhalation, systemic effects
In a 90-day oral toxicity study performed in rats with sodium thioglycolate, the NOAEL for systemic toxicity was 20 mg/kg bw/day.
No difference between oral and inhalation absorption is assumed.
NOAELRat= 20 mg/kg bw/day
Conversion into inhalatory NOAEC (in mg/m³) by using an 8-hour standard respiratory volume for the rat
Correction for differences between oral and inhalation absorption
Correction for differences in 8-hour inhalative volumes between workers in rest and workers under light activity
0.38 m³ /kg bw
6.7 m³ / 10 m³
(20 x 1/0.38 x 1 x 6.7/10 x 1/(2.5 x 7 x 5 x 2 x 1 x 1))
Dermal, local effects
In a 90-day dermal toxicity study perfomed in rats with sodium thioglycolate, the LOEL for local effects at the site of application (skin irritation) was 11.25 mg/kg bw.
LOELRat= 11.25 mg/kg bw/day
Modification to LOEL for dermal irritation (in mg/cm²/day)
0.25 kg / 44.5 cm²
Interspecies (local effects)
Dose response (LOEL/NAEL extrapolation)
(11.25 x 0.25/44.5 x 1/(1 x 5 x 1 x 3 x 1))
DNELs for the general population have not been proposed because thioglycolates are generally used as an ingredient in cosmetic products. According to Article 14, paragraph 5(b) of of Regulation (EC) No.1907/2006, the chemical safety report does not need to include considerations of the risk to human health from end uses in cosmetic products within the scope of Directive 76/768/EEC.
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