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EC number: 430-010-4
CAS number: 12160-44-0
The water solubility of the test substance is very low. The test media were analysed for iron content in order to demonstrate equilibration and stability of iron potassium oxide during the tests. Throughout the test no dissolved iron was detected at or above the Iimit of determination of 0.1 mg/L at the single loading rate of 1000 mg/L. No mortality or any other effects were noted in rainbow trout exposed for 96 hours to a WAF prepared at a loading rate of 1000 mg/L. Therefore, an LC50 value cannot be reliably determined from the test. According to REACH guidance R7a (Appendix 7.8-1) for substances that show no effect at the limit of solubility, and for which all reasonable efforts were made to obtain and maintain the highest possible concentration over the whole test duration, the limit value is to be used for risk assessment. As these criteria were met, the 96-h LC50 for fish is determined at >1.0 mg/L (limit of solubility).
Acute toxicity to fish of the test substance was determined in a limit
test performed according to the OECD guideline 203 and in compliance
with GLP criteria. As the test substance was sparingly soluble in water,
a water accommodated fraction was produced using a loading rate of 1000
mg/L. Rainbow trout (7 per concentration) were exposed to the test
medium and a control for 96 hours under semi-static conditions. Samples
for analysis of the actual concentration were taken every 24 hours (just
before and just after renewal of test media). At the loading rate of
1000 mg/L, analytical concentrations of dissolved iron were below the
Iimit of detection (0.1 mg/L) in all except one of the fresh and aged
test solutions (a value of 0.1 mg/L was measured in the fresh test
medium on the first day). The concentrations of suspended iron ranged
from 0.88- 2.3 mg/L in the freshly prepared solutions and from 0.30-
0.63 mg/L in the aged solutions as a result of a fine film of test
compound coating the bottom of the test vessel.In the exposure group one
fish showed minor toxic effects until 72 hours after exposure. At 96
hours these signs were no longer observed. No mortalities occurred.
Based on these findings the LC50 is determined at > 1000 mg/L (based on
the loading rate).
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