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EC number: 257-856-5 | CAS number: 52334-81-3
Non Abraded Skin
No signs of irritation were seen in any animal following a single 24-hour application to intact rat skin.
Repeated application (x5)
One animal only showed signs of irritation following repeated 24 hour applications to intact rat skin, these signs included erythema, desquamation and scabbing, and the animal had not recovered by the end of the study period.
In conclusion the neutralised product from acid extraction before steam distillation is no irritant to intact rat skin following a single application and is practically non-irritant to intact rat skin following repeated applications.
Immediately following a single 24-hour application to abraded rat skin, one animal showed signs of slight erythema but this did not persist. No other signs of irritation were seen in any other animal.
One animal appeared slightly sensitive to touch on Day 5 prior to the third application of the test substance to abraded skin. No other signs of irritation was observed in any animal during the study period.
In conclusion, the neutralised product from acid extraction before steam distillation is practically non-irritant to abraded rat skin following both single and repeated 24-hour applications.
The neutralised product from acid extraction before steam distillation is a process stream in the manufacture of 2-chloro-5-trifluoromethylpyridine (CTF). This process stream contains largely trifluoromethylpyridines, including some 23.2% CTF. In single and repeated dose tests on intact and abraded rat skin this process stream was shown to be practically non-irritant. This result provides supporting evidence that CTF itself is unlikely to cause skin irritation.
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