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EC number: 257-856-5 | CAS number: 52334-81-3
After application to the skin membranes of CTF as a 2.5mg/ml solution in acetone (which was allowed to evaporate away) the mean rate of absorption of CTF through human epidermal membranes was:
0.0070 mg/cm2/hr (SEM ± 0.0011 : n=11)
When similarly applied to rat whole skin the mean rate of absorption was:
0.0062 mg/cm2/hr (SEM ± 0.00008 : n = 20)
When applied to separated rat epidermal membranes the mean rate of absorption of CTF was:
0.0053 mg/cm2/hr (SEM ± 0.00096 : n=7)
The mean damage ratio due to contact of CTF with the skin membranes was:
Human epidermal membranes: 4.25 (SEM ± 2.4 : n = 3)
Rat whole skin: 2.19 (SEM ± 0.12 : n = 4)
Separated rat epidermal membranes: 4.01 (SEM ± 0.87 : n = 7)
Contact with ethanol/water (50/50 v/v) alone produces a damage ratio of ~ 2.0
2-chloro-5-(trifluoromethyl) pyridine (CTF) was applied in acetone (2.5mg/ml) to prepared human and rat epidermal membranes in glass diffusion cells. The mean in vitro percutaneous absorption rate of CTF was
0.0070mg/cm2/hr (SEM ± 0.011 : n = 11) through human skin
0.0053mg/cm2/hr (SEM ± 0.0096 : n = 11) through rat skin
These results indicate that CTF penetrated both these skin types slowly.
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