6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-01-29 to 2013-02-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 59

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

Type of distribution:

mass based distribution

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

The different sieving fractions were as follows:

over        3150µm                 0.00 %

fraction  1400 - 3150 µm    67.78 %

fraction    1000 - 1400µm   14.53 %

fraction      710 - 1000µm    4.55 %

fraction      500 - 710µm     6.06 %

fraction       300 - 500µm     5.63 %

fraction       125 - 300µm     3.64 %

fraction         45 - 125 µm    0.80 %

under                   45µm        0.00 % Most oft the particles had a size between 1400 and 3150 µm. There were no particles smaller than 45 µm. Thus, all particles are larger than the small respirable fraction (< 2 µm).

Conclusions:

Most of the particles had a size between 1400 and 3150 µm. There were no particles smaller than 45 µm. Thus, all particles are larger than the small respirable fraction (< 2 µm).

Executive summary:

The particle size distribution of TC was determined using the dry sieve test in accordance with the guideline CIPAC MT 59. The tested material was sieved using a set of sieves with different size exclusion sizes (45µm, 300 µm, 500 µm, 710 µm, 1000µm,1400 µm and 3150µm). At the end of the sieving procedure for 5 minutes, the content of each sieve was weighed. Two replicates were performed and the result was given as an average of these two. Most of the particles had a size between 1400 and 3150 µm. There were no particles smaller than 45 µm. Thus, all particles are larger than the small respirable fraction (< 2 µm).

This study is considered not relevant in the evaluation of the marketed substance because the substance is marketed as a wet press cake containing water.

Description of key information

The particle size distribution of 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid (TC) was determined using the dry sieve test in accordance with the guideline CIPAC MT 59. The tested material was sieved using a set of sieves with different size exclusion sizes (45µm, 300 µm, 500 µm, 710 µm, 1000µm, 1400 µm and 3150µm). At the end of the sieving procedure for 5 minutes, the content of each sieve was weighed. Two replicates were performed and the result was given as an average of these two. Most of the particles had a size between 1400 and 3150 µm. There were no particles smaller than 45 µm. Thus, all particles are larger than the small respirable fraction (< 2 µm).