Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-848-9
CAS number: 52479-58-0
There was no mortality. Signs of reaction to treatment observed in all
rats five minutes after dosing were piloerection, abnormal body carriage
(hunched posture) and abnormal gait (waddling). Increased salivation was
also observed in all male rats and one female. Piloerection was the only
clinical siqn to persist from one hour after dosing. Recovery, as judged
by external appearance and behaviour, was complete by Day 3. 5/5 males
showed expected gains in bodyweight over the study period. In the first
and second weeks of the observation period for single female rats
slightly low body weight gains were recorded. No abnormalities were
noted at necropsy
The acute oral median lethal dose (LD50) of Polyol TP30 in the rat was
found to be >5000 mg/kg bw with regard to a limit test according to OECD
TG 401. A dose of 5000 mg/kg bw was tolerated without mortalities and
gross pathological findings. Effects on weight gain were restricted to
single female rats. Clinical observation revealed hunched posture,
abnormal gait and piloerection.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again