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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
one-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Theoretical modelling using MC4PC version 2.1 Artificial intelligence based bioactivity software
MultiCASE Inc, 23811 Chagrin Blvd Ste 305,
Beachwood, Ohio, 44122, USA www.multicase.com
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous

Test animals

Sex:
male/female

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Key result
Dose descriptor:
NOAEL
Effect level:
1 other: no unit, this is filled to pass TCC as the remark in the Remarks field is not preventing TCC failure.
Based on:
not specified
Sex:
male/female
Basis for effect level:
other: Effect levels were not determined. Modelling tool does not allow this determination.
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
NOAEL
Generation:
F1
Effect level:
1 other: no unit
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: Effect levels were not determined. Modelling tool does not allow this determination.
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Three models were used to assess reprotoxicity of N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine and all three predict that the molecule has no structural features associated with reproductive toxicity.
Executive summary:

Three models were used to assess reprotoxicity of N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine and all three predict that the molecule has no structural features associated with reproductive toxicity.