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EC number: 212-855-9 | CAS number: 873-94-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964-12-02 - 1965-01-1
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3,5-trimethylcyclohexan-1-one
- EC Number:
- 212-855-9
- EC Name:
- 3,3,5-trimethylcyclohexan-1-one
- Cas Number:
- 873-94-9
- Molecular formula:
- C9H16O
- IUPAC Name:
- 3,3,5-trimethylcyclohexan-1-one
- Details on test material:
- Test substance: other TS: Origin: Esso Research and Engineering Company, 2 Dec 1964,
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Weight at study initiation: 200-225 grams
- Number of animals: 10
- Controls: yes
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- - Type of exposure: inhalation, aerosol (mist)
- The test atmosphere is not well characterized. However, due to a saturation vapour pressure of 3.45 mg/l and the applied technique (use of precision metering pump into a stainless steel spray nozzle tip) it can be concluded that the atmosphere was a mist rather than a vapour. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- - Concentrations: 11.5; 15; 18 mg/l
- No. of animals per sex per dose:
- 10 males
- Control animals:
- yes
- Details on study design:
- EXAMINATIONS:
- Observations for deaths and toxic signs: 30 min intervals
- post observation: 14 days, daily
- gross pathology: at end of post observation period: all surviving animals
- vaporization of the material was achieved by means of a precision metering pump into a stainless steel spray nozzle tip. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 14.2 mg/L air (nominal)
- Exp. duration:
- 4 h
- Remarks on result:
- other: aerosol
- Mortality:
- - Number of deaths at each dose, time of death:
11.5 mg/L: 4 hours = 0; 14 days = 0 death
15.0 mg/L: 4 hours = 0; 14 days = 8 deaths
18.0 mg/L: 4 hours = 10 deaths
LD50 confidence intervals: 12.6 - 16.0 mg/L; slope function 1.18 - Clinical signs:
- other: During exposure, the animals generally exhibited hyperactivity and towards the end of the exposure became prostrate and comatose. Following exposure, the anomals showed depression and decrease of activity, piloerection and weight loss.
- Body weight:
- weight loss
- Gross pathology:
- Autopsy of the high dose animals revealed moderate atelectasis of the lung and congestion of the kidneys, findings in surviving animals were not significant.
- Other findings:
- no other findings
Any other information on results incl. tables
no remarks
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the LC50 of 3,3,5-trimethylcyclohexanone after exposure by inhalation was determined to be 14.2 mg/l in male rats.
- Executive summary:
Groups of 10 male rats were exposed to 3,3,5-trimethylcyclohexanone for 4 hours by whole body exposure. The observation period was 2 weeks. At a concentration of 11.5 mg/l no animal died. At a concentration of 15.0 mg/l 80 % of the rats died after the observation period of 14 days. At very high concentrations of 18.0 mg/l all animals died within 4 hours. Clinical signs were depression and decrease of activity, piloerection and weight loss. At necropsy of the high exposure concentrations, moderate atelectasis of the lung and congestion of the kidneys were notified, surviving animals were not significant
Therefore, under the conditions of this study the LC50 of 3,3,5 -trimethylcyclohexanone after inhalative exposure in rats was 14.2 mg/l.
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