Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity was assessed in a limit test according to OECD 401 (Hüls, 1995). The LD 50 was above 2000 mg/kg bw. 
Acute toxicity by inhalation was assessed in an acute inhalation toxicity study similar to OECD 403 (Hazleton, 1965). An LC 50 of 14.2 mg/l was concluded.
The dermal route was assessed in a limit test according to OECD 402 (Hüls, 1996). The LD50 was above 2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
14 200 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute toxicity tests conducted in Wistar rats are available for all three routes. All studies are conducted similar or according to OECD guidelines. Both LD50 values for the oral and the dermal route were above a limit dose of 2000 mg/kg bw. An LC50 value for toxicity by inhalation could be derived (14.2 mg/l ).

Justification for classification or non-classification

An LC 50 of 14.2 mg/l has been concluded for 3,3,5-trimethylcyclohexanone. According to Regulation (EC) No 1272/2008 it has not been classified.

LD 50 values for oral and dermal exposure are above the limit dose of 2000 mg/kg bw. A classification is not warranted for these routes.