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Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

General principle of read-across is based on: (1) similar physicochemical properties, (2) structural analogy and (3) similar mode of action in the body (toxico-kinetics; biotransformation).

In the case of PG and HPGds, these are all fulfilled:

-         Physicochemical parameters were determined;

-         Structural similarity is obvious;

-         Mode of action/bioavailability/~transformation is the same (action) and not assumed to behave differently.

 

See the attached documentation for read-across specific motivation for registration of PGds.

 

Read-across proposed have been checked using the OECD Toolbox v. 1.1.01 and the outcome was the same for both substance.

Dane salts are hydrolysing substances designed to protect a functional group during chemical synthesis, and to easily release the parent molecule. So they can be expected to behave as the parent molecule, as hydrolysis will occur in living organisms or in environment.

Read across from D(-)-p-hydroxyphenylglycine Dane salt (K, methyl, CAS n° 69416-61-1) to D(-)-alpha-phenylglycine Dane salt (K, ethyl, CAS n° 961-69-3) is supported, beyond the structural similarity, by the following mechanistic criteria, similarities, as evaluated by the OECD Toolbox:

-        Protein binding: potentially can cause skin sensitization as a result of protein conjugation via Michael-type nucleophilic addition

-        No DNA binding potential

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